BEX and immunology

 https://www.jnj.com/innovation/the-future-of-immunology 

"Protecting from invaders and surveilling for other threats is a big job—and it’s what your immune system, your body’s very own built-in defense mechanism, does every day. When you catch a cold or other viral infection, for instance, your immune system mounts a response that mobilizes killer T cells and triggers the release of antibodies, which identify the virus as harmful and destroy it. Mission accomplished. Your immune system then quiets back down and you feel better.

If you have an autoimmune condition, however, that’s not what happens.

Instead, your immune system mistakenly treats your body’s normal tissue as an invader and attacks it, which causes chronic inflammation. Research published in The Lancet in 2023 suggests one in 10 people around the world live with an autoimmune disease, an umbrella term that pertains to over 100 conditions

The most common antibody is immunoglobulin G (IgG) and the body uses it to fight off invaders such as bacterial and viral infections. If you contract COVID-19, the flu or any other contagious ailment, for instance, your body will start making IgG about 24 to 48 hours later. But if you have an autoantibody disease—a subset of autoimmune diseases—your body produces pathogenic IgGs, also known as autoantibodies, that attack its own critical organs and tissues."  

Bexmarilimab is an antibody, immunoglobulin IgG4, but

IT ACTS ON A NOVEL MECHANISMS via Clever-1

  

CLEVER-1 is an immunosuppressive receptor on macrophages immune cells, responsible for eliminating infected or cancerous cells. Bexmarilimab inhibits CLEVER-1, reprogramming macrophages/monocytes from an immune suppressive to an immune activating state

The change in the state of monocytes activates the immune system to find and destroy cancer cells 

Bexmarilimab deactivates the energy production of the cancer cells, enabling existing therapies (ie. AZA), which previously did not work, to destroy cancer cells

BEX is multifunctional (and more functions are in progress!)

BUT THERE MIGHT BE ON ISSUE CONCERNING IgG4

https://www.science.org/doi/10.1126/sciimmunol.adg7327  

Is it bad, is it good, or is IgG4 just misunderstood? 

It is under discussions, BUT BEX IS WELL TOLERATED